AI Article Synopsis
- Breast cancer (BC) is influenced by various genetic and environmental factors, and this study focuses on the relationship between a specific DNA variation (VNTR) in a certain gene and the risk of developing BC among Jordanian women.
- Using techniques like Polymerase Chain Reaction and Gel electrophoresis, researchers analyzed genetic samples from 200 BC patients and 200 healthy controls, revealing a significant correlation between the VNTR polymorphism and increased BC risk.
- Results showed three specific genotypes were notably linked to BC, but the study suggests that while the VNTR may affect BC development, it does not impact prognosis and further research is needed to understand this genetic variant's role in cancer formation.
Article Abstract
Purpose: Breast cancer (BC) is a complex disease that is governed by several different environmental and inherited factors. There are many genes have been linked with BC development by screening specific genetic variants within these genes. In this study, we aim to investigate the correlation between Variable Number Tandem Repeat (VNTR) in gene and BC.
Materials And Methods: Polymerase Chain Reaction (PCR) and Gel electrophoresis were used to genotype the gene polymorphism in 200 cases with breast cancer and 200 healthy individuals. All participants were Jordanian women from Arab descents. Clinical and pathological characteristics for BC patients were summarized and categorized according to their medical records.
Results: In this study, we found a strong correlation between the VNTR polymorphism in the gene and BC risk (value<0.0001). Remarkably, three different genotypes (2R\2R, 3R\2R and 3R\3R) showed significant association with BC (value<0.0001). This study also reported a significant difference in the distribution of allele frequencies between BC patients and healthy individuals (3R; value<0.0001 and 2R; value<0.001). However, we propose that VNTR of gene did not interfere with BC prognosis.
Conclusion: We speculate that the VNTR of gene may influence BC development. More investigations are needed in this regard to clarify the underlying role of the genetic variant in tumorgenesis including BC development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936298 | PMC |
| http://dx.doi.org/10.2147/OTT.S220226 | DOI Listing |
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