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Patient-derived xenograft models-the future of personalised cancer treatment. | LitMetric

Patient-derived xenograft models-the future of personalised cancer treatment.

Br J Cancer

Department of Oncology, Charing Cross Hospital, Imperial College and Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK.

Published: March 2020

AI Article Synopsis

Article Abstract

For many tumours there is a lack of randomised data from which we can guide systemic treatments. Although gene expression profiling along with proteomics has led to advances in diagnosis, classification and prognosis, our ability to target many cancers has been further limited due to a lack of therapeutic options. The use of patient-derived xenograft (PDX) models in the setting of a rare malignancy is discussed here by Kamili et al, with the successful establishment of new model systems.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054515PMC
http://dx.doi.org/10.1038/s41416-019-0678-0DOI Listing

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