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Institute of Science and Technology Research, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501 Japan.

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The multiple faces of RAGE--opportunities for therapeutic intervention in aging and chronic disease.

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a Diabetes Research Program, Division of Endocrinology, Department of Medicine , New York University Langone Medical Center, New York , NY 10016 , USA.

Introduction: This review focuses on the multi-ligand receptor of the immunoglobulin superfamily--receptor for advanced glycation endproducts (RAGE). The accumulation of the multiple ligands of RAGE in cellular stress milieux links RAGE to the pathobiology of chronic disease and natural aging.

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