A large solitary mesothelioma was found to exhibit malignant features microscopically, but benign characteristics grossly, including a surgically curative resection. The mixed behavior of this tumor supports the evolving understanding of mesotheliomas as progeny of multipotential subserosal cells with capabilities of differentiating into several tissue types with varying degrees of anaplasia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1378/chest.94.6.1293 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pleural Rosai-Dorfman disease complicated with renal clear cell carcinoma: a case report and literature review.
Front Oncol
January 2025
Department of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Background: Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare non-malignant disorder characterized by excessive proliferation of histiocytes, the cause of which remains unknown. Although the lymph nodes are the most commonly affected site, some patients may present with extranodal involvement, particularly in the skin, nasal cavity, eyes, and bones. In this report, we aim to present a unique case of RDD with pleural involvement in a 61-year-old patient.
View Article and Find Full Text PDFBRCA1-associated-protein-1 inactivated melanocytic tumours: characterisation of the clinicopathological spectrum and immunohistochemical expression pattern of preferentially expressed antigen in melanoma.
Histopathology
January 2025
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
Aims: BRCA1-associaed protein-1 (BAP1) inactivated tumours (BIMT) are rare melanocytic tumours that may be mistaken for Spitz tumours or melanoma. They occur sporadically or in association with the BAP1 tumour predisposition syndrome (BAP1-TPDS), which may be complicated by uveal or cutaneous melanoma, mesothelioma, basal cell carcinoma and renal cell carcinoma. The aim of this study was to characterise the clinicopathological features and the immunohistochemical expression pattern of preferentially expressed antigen in melanoma (PRAME) of BIMT in a large patient cohort.
View Article and Find Full Text PDFImmunohistochemical Evaluation of Schlafen 11 (SLFN11) Expression in Cancer in the Search of Biomarker-Informed Treatment Targets: A Study of 127 Entities Represented by 6658 Tumors.
Am J Surg Pathol
August 2024
Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
Article Synopsis
- Schlafen 11 (SLFN11) is a helicase that regulates how cells respond to stress during DNA replication, and its expression can predict treatment outcomes in cancer patients receiving certain therapies.
- In a study involving 6,658 tumors, SLFN11 was found to be rare in common epithelial tumors (e.g., breast and prostate cancers) but prevalent in several more aggressive tumors and specific mesenchymal and neuroectodermal cancers.
- The absence of SLFN11 may lead to worse outcomes for patients treated with DNA-damaging drugs, suggesting the need for alternative treatments for those cancers that lack this biomarker.
Contemporary management of mesothelioma.
Breathe (Sheff)
June 2024
Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK.
Pleural mesothelioma (PM) is an aggressive asbestos-associated thoracic malignancy with a median survival of 12-18 months. Due to continued asbestos use in many nations, global incidence is rising. Causes due to non-occupational, environmental exposure are also rising in many countries despite utilisation bans.
View Article and Find Full Text PDFDendritic Cell-Based Immunotherapy in Patients With Resected Pancreatic Cancer.
J Clin Oncol
September 2024
Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Purpose: Immunotherapies have shown limited responses in patients with advanced pancreatic cancer. Recently, we reported that dendritic cell (DC)-based immunotherapy induced T-cell responses against pancreatic cancer antigens. The primary objective of this study was to determine the efficacy of DC-based immunotherapy to prevent recurrence of disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!