AI Article Synopsis
- The research investigates how cerebrospinal fluid (CSF) circulation influences body axis formation and brain development in 30-hour post-fertilization zebrafish embryos.
- It finds that local motile cilia in the spinal cord's central canal generate a unique bidirectional CSF flow, which is explained by the canal's closed geometry.
- The study concludes that cilia activity, along with muscle contractions, plays a crucial role in transporting lipidic particles, which is essential for proper embryonic development.
Article Abstract
Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord of 30 hpf zebrafish embryos and its impact on development. Experiments combined with modeling and simulations demonstrate that the CSF flow is generated locally by caudally-polarized motile cilia along the ventral wall of the central canal. The closed geometry of the canal imposes the average flow rate to be null, explaining the reported bidirectionality. We also demonstrate that at this early stage, motile cilia ensure the proper formation of the central canal. Furthermore, we demonstrate that the bidirectional flow accelerates the transport of particles in the CSF via a coupled convective-diffusive transport process. Our study demonstrates that cilia activity combined with muscle contractions sustain the long-range transport of extracellular lipidic particles, enabling embryonic growth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989091 | PMC |
| http://dx.doi.org/10.7554/eLife.47699 | DOI Listing |
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