Crokonoid A (), a highly rearranged diterpenoid featuring a dual-bridged tricyclo[4.4.1.1]dodecane-2,11-dione ring system and its two possible -kaurene diterpenoid precursors ( and ), was isolated and structurally characterized by solid data from . Compound exhibited significant cytotoxicity against HL-60 and A-549 cell lines with IC values of 1.24 ± 0.56 and 1.92 ± 0.60 μM, respectively.
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| http://dx.doi.org/10.1021/acs.orglett.9b04484 | DOI Listing |
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