Background: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. Immune reconstitution is an important event that determines outcomes. The immune recovery of T cells relies on peripheral expansion of mature graft cells, followed by differentiation of donor-derived hematopoietic stem cells. The formation of new T cells occurs in the thymus and as a byproduct, T cell receptor excision circles (TRECs) are released. Detection of TRECs by PCR is a reliable method for estimating the amount of newly formed T cells in the circulation and, indirectly, for estimating thymic function. The aim of this study was to determine the role of TREC quantitation in predicting outcomes of human leucocyte antigen (HLA) identical allogenic HSCT.
Methods: The study was conducted on 100 patients receiving allogenic HSCT from an HLA identical sibling. TREC quantification was done by real time PCR using a standard curve.
Results: TREC levels were inversely related to age (=0.005) and were significantly lower in patients with malignant diseases than in those with benign diseases (=0.038). TREC levels could predict relapse as an outcome but not graft versus host disease (GvHD) and infections.
Conclusion: Age and nature of disease determine the TREC levels, which are related to relapse.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942145 | PMC |
| http://dx.doi.org/10.5045/br.2019.54.4.274 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cortisol and C-reactive protein (CRP) regulation in severe mental disorders.
Psychoneuroendocrinology
December 2024
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address:
Background: People with schizophrenia (SZ) and bipolar disorder (BD) show abnormalities in the biological stress system and low-grade inflammation. However, whether the hypothalamic-pituitary-adrenal (HPA) axis-immune regulation is disrupted in SZ and BD, is yet to be determined.
Methods: Cortisol and C-reactive protein (CRP) were measured in blood samples collected at or before 10 am in participants with SZ (N = 257), BD (N = 153), and healthy controls (N = 40).
A multi-dimensional semantic pseudo-relevance feedback framework for information retrieval.
Sci Rep
December 2024
Information Retrieval and Knowledge Management Research Lab, School of Information Technology, York University, Toronto, Canada.
Pre-trained models have garnered significant attention in the field of information retrieval, particularly for improving document ranking. Typically, an initial retrieval step using sparse methods such as BM25 is employed to obtain a set of pseudo-relevant documents, followed by re-ranking with a pre-trained model. However, the semantic information captured by pre-trained models from sentences or passages is usually only applied to document ranking, with limited use in query expansion.
View Article and Find Full Text PDFSafety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial.
EBioMedicine
December 2024
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address:
Background: The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe COVID-19.
View Article and Find Full Text PDFPerspectives in newborn screening for SCID in Japan. Case report: newborn screening identified X-linked severe combined immunodeficiency with a novel variant.
Front Immunol
December 2024
Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Background: Newborn screening (NBS) for severe combined immunodeficiency (SCID) has improved the prognosis of SCID. In Japan, NBS testing (measurement of the T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC)) was launched in 2017 and has expanded nationwide in recent years. In this study, we report a Japanese patient with X-linked SCID with a novel variant identified through NBS.
View Article and Find Full Text PDFDetection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling.
Immun Ageing
November 2024
Centre for Intelligent Healthcare, Coventry University, Priory Street, COVENTRY, CV1 5FB, Conventry, UK.
Article Synopsis
- Immune function declines with age, making it difficult to identify individuals at risk for immune-related issues, especially those with reactivated latent viral infections.
- The study focused on detecting certain human herpes viruses in urine as a potential way to identify immune-compromised individuals, particularly using T cell receptor excision circle (TREC) data as an indicator.
- While no clear one-to-one correlation was found between TREC values and individual viruses, a significant link was observed for males; specifically, low TREC values correlated with the detection of three or more different herpes viruses, suggesting declining immune function.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!