PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus.

Objectives: To investigate whether the presence of peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms is associated with unexplained mild visual impairment (UMVI) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 135 T2DM residents with UMVI and 133 with normal vision (NV; best-corrected visual acuity ≥ 20/25 in both eyes) were enrolled. UMVI was defined as best-corrected visual acuity (BCVA) < 20/25 and ≥ 20/63 in both eyes, with no visual impairment-causing diseases found. Four PPARG gene single-nucleotide polymorphisms (SNPs) (rs3856806, rs1801282, rs709158, and rs10865710) were assessed with the HAPLOVIEW 4.0 software to examine the statistical association of PPARG polymorphisms and UMVI in patients with T2DM.

Results: Four SNPs qualified the Hardy-Weinberg equilibrium ( > 0.05). The frequency of genotype GC at SNP rs10865710 was significantly higher in the UMVI group than in the NV group ( < 0.001; GG + GC versus CC) (OR = 8.94, 95% CI: 4.90-16.31), whereas genotype CC decreased the risk (OR = 0.07, 95% CI: 0.03-0.14). Genotype TT at SNP rs3856806 was strongly associated with UMVI ( < 0.0001, TT + TC versus CC) (OR = 4.74, 95% CI: 2.68-8.54), whereas genotype CC appeared to be protective for UMVI (OR = 0.55, 95% CI: 0.37-0.82).

Conclusions: Susceptibilities of PPARG variants may lead to differences in PPARG transcription, result in early function loss of retinal photoreceptor cells, and eventually cause UMVI.