AI Article Synopsis
- Maturity-onset diabetes of the young (MODY) is a rare type of diabetes caused by genetic mutations affecting insulin-producing cells and it makes up about 2%-5% of diabetes cases.
- Identifying MODY can be tricky since it overlaps with type 1 and type 2 diabetes, but genetic testing, particularly Sanger DNA sequencing, is the best method for diagnosis.
- The review highlights differences in genetic causes of MODY between Asian and Caucasian populations, and stresses the need for more research on MODY's prevalence in Asian groups.
Article Abstract
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by ß-cell dysfunction. MODY accounts for between 2% and 5% of all diabetes cases, and distinguishing it from type 1 or type 2 diabetes is a diagnostic challenge. Recently, MODY-causing mutations have been identified in 14 different genes. Sanger DNA sequencing is the gold standard for identifying the mutations in MODY-related genes, and may facilitate the diagnosis. Despite the lower frequency among diabetes mellitus cases, a correct genetic diagnosis of MODY is important for optimizing treatment strategies. There is a discrepancy in the disease-causing locus between the Asian and Caucasian patients with MODY. Furthermore, the prevalence of the disease in Asian populations remains to be studied. In this review, the current understanding of MODY is summarized and the Asian studies of MODY are discussed in detail.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986955 | PMC |
| http://dx.doi.org/10.12701/yujm.2019.00409 | DOI Listing |
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