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Slow-moving tropical cyclones (TCs) can cause heavy rain because of their duration of influence. Combined with expected increase in rain rates associated with TCs in a warmer climate, there is growing interest in TC translation speed in the past and future. Here we present that a slowdown trend of the translation speed is not simulated for the period 1951-2011 based on historical model simulations. We also find that the annual-mean translation speed could increase under global warming. Although previous studies show large uncertainties in the future projections of TC characteristics, our model simulations show that the average TC translation speed at higher latitudes becomes smaller in a warmer climate, but the relative frequency of TCs at higher latitudes increases. Since the translation speed is much larger in the extratropics, the increase in the relative frequency of TCs at higher latitudes compensates the reduction of the translation speed there, leading to a global mean increase in TC translation speed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949250 | PMC |
http://dx.doi.org/10.1038/s41467-019-13902-y | DOI Listing |
Sci Rep
March 2025
Ludwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090, Vienna, Austria.
Duchenne muscular dystrophy (DMD), a severe muscle disease caused by mutations in the gene encoding for the intracellular protein dystrophin, is associated with impaired cardiac function and arrhythmias. A causative factor for complications in the dystrophic heart is abnormal calcium (Ca) handling in ventricular cardiomyocytes, and restoration of normal Ca homeostasis has emerged as therapeutic strategy. Here, we used a rodent model of DMD, the dystrophin-deficient DMD rat, to test the following hypothesis: chronic administration of ivabradine (IVA), a drug clinically approved for the treatment of heart failure, improves Ca handling in dystrophic ventricular cardiomyocytes and thereby enhances contractile performance in the dystrophic heart.
View Article and Find Full Text PDFFront Neurol
February 2025
Division of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Vestibular deficits often lead to unsteady gait, affecting quality of life and increasing fall risk. This study aimed to identify gait impairments in chronic vestibulopathy. Ten patients with bilateral vestibulopathy (BV), 10 patients with chronic unilateral vestibulopathy (UV), and 10 healthy participants (HS) participated.
View Article and Find Full Text PDFCardiovasc Pathol
March 2025
Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, 2610, Antwerp, Belgium; Department of Cardiology, Antwerp University Hospital, 2650, Antwerp, Belgium.
Background And Aims: Myocarditis is a group of inflammatory diseases of the myocardium, with viral infections being the leading cause. Previous murine studies have demonstrated a detrimental effect of extensive exercise on the acute course of viral myocarditis. Recently, we were the first to report that continuation of moderate exercise during murine viral myocarditis modulates myocardial inflammation and fibrosis at the late stage of disease, yet we did not evaluate early time points.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Melanoma is the deadliest form of skin cancer, and its treatment poses significant challenges due to its aggressive nature and resistance to conventional therapies. Long non-coding RNAs (lncRNAs) represent a new frontier in the search for suitable targets to control melanoma progression and invasiveness. Indeed, lncRNAs exploit a wide range of regulatory functions along chromatin remodeling, gene transcription, post-transcription, transduction, and post-transduction to ultimately tune multiple cellular processes.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Hospital Therapy No. 1 Department, N.V. Sklifosovskiy Institute of Clinical Medicine, I.M. Sechenov First Moscow Medical University (Sechenov University), 119991 Moscow, Russia.
The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. The use of metabolomics approaches seems promising in speeding up and simplifying the diagnostic process in HFpEF patients, which can lead to earlier treatment initiation and better improvement of patient condition. The aim of this study was to develop a diagnostic panel of metabolites (metabolomic biomarkers) for the detection and diagnosis of HF with preserved ejection fraction.
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