AI Article Synopsis
- The study isolated two new compounds from black tubers that demonstrated significant antibacterial properties, particularly one compound matching the effectiveness of ampicillin.
- Both compounds also exhibited notable antifungal activity, outperforming fluconazole against specific strains.
- This research marks the first report of these compounds exhibiting antimicrobial activities, suggesting potential for future therapeutic applications.
Article Abstract
Activity-guided fractionations of black tubers of led to the isolation of 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl] benzonitrile () and [3,5- (1,1-dimethylethyl)-4-hydroxyphenyl] ethenylidene] -phosphonic acid tetraethyl ester (). Compounds and showed an antibacterial effect against almost all the strains assayed, especially compound showing the same inhibition potential for and as the ampicillin (MIC = 1.5 μM) and a better potential than chloramphenicol which has a MIC of 3.5 μM. In addition, compounds 1 and 2 showed a relevant antifungal inhibition against with MICs of 100 μM and 50 μM, and against with MICs of 25 μM and 1.5 μM. This is in comparison to fluconazole which had MICs of 150 μM (against ) and 3.5 μM (against ). This is the first time that compounds and are reported as showing antimicrobial activities.
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| http://dx.doi.org/10.1080/14786419.2019.1710700 | DOI Listing |
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