Stereolithography (SL) has several advantages over traditional biomanufacturing techniques such as fused deposition modeling, including increased speed, accuracy, and efficiency. While SL has been broadly used in tissue engineering for the fabrication of three-dimensional scaffolds that can mimic the environment for cell growth and tissue regeneration, lithographic printing is usually performed on single-component materials cured with ultraviolet light, severely limiting the versatility and cytocompatibility of such systems. In this study, we report a highly tunable, low-cost photoinitiator system that we used to establish a systematic library of crosslinked materials based on low molecular weight poly(ethylene glycol) diacrylate. We assessed the physicochemical properties, photocrosslinking efficiency, cost performance, and biocompatibility to demonstrate the capability of manufacturing a multimaterial complex tissue scaffold. [Figure: see text] Impact statement Stereolithography (SL) has advantages over traditional biomanufacturing techniques, including accuracy and efficiency. While SL has been broadly used for fabricating three-dimensional scaffolds that can mimic the environment for cell growth and tissue regeneration, lithographic printing is usually performed on single-component materials cured with ultraviolet light, severely limiting the versatility and cytocompatibility of such systems. In this study, we report a highly tunable photoinitiator system and establish a systematic library of crosslinked materials based on poly(ethylene glycol) diacrylate. We assessed the physicochemical properties, photocrosslinking efficiency and biocompatibility to demonstrate the capability of manufacturing a multimaterial complex tissue scaffold.
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http://dx.doi.org/10.1089/ten.TEA.2019.0282 | DOI Listing |
Mikrochim Acta
December 2024
Department of Pharmaceutics, SCSSS's Sitabai, Thite College of Pharmacy, Shirur-412210, Dist-Pune, Maharashtra, India.
Cancer is a major cause of death globally, and early detection is a key to improving outcomes. Traditional diagnostic methods have limitations such as being invasive and lacking sensitivity. Immunosensors, which detect cancer biomarkers using antibodies, offer a solution with high sensitivity and selectivity.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Institute of Advanced Materials (INAM), Universitat Jaume I (UJI), Avenida de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.
Rapid prototyping techniques offer significant advantages in terms of fabrication speed, accessibility, and low cost. This study explores the use of low-cost stereolithographic resins to produce prototypes intended for underwater conditions. The objective is to evaluate the feasibility of different low-cost resin brands by identifying their water absorption percentage and their response in terms of appearance and deformation after prolonged exposure to an underwater environment.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Division of Vascular Surgery, Department of General Surgery and Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Constructing scaffolds with the desired structures and functions is one of the main goals of tissue engineering. Three-dimensional (3D) bioprinting is a promising technology that enables the personalized fabrication of devices with regulated biological and mechanical characteristics similar to natural tissues/organs. To date, 3D bioprinting has been widely explored for biomedical applications like tissue engineering, drug delivery, drug screening, and in vitro disease model construction.
View Article and Find Full Text PDFBioengineering (Basel)
October 2024
BMF Biotechnology, Inc., San Diego, CA 92121, USA.
In this study, we present a novel 3D perfused skin-on-a-chip model fabricated using micro-precision 3D printing, which offers a streamlined and reproducible approach for incorporating perfusion. Perfused skin models are well-regarded for their advantages, such as improved nutrient supply, enhanced barrier function, and prolonged tissue viability. However, current models often require complex setups, such as self-assembled endothelial cells or sacrificial rods, which are prone to variability and time-consuming.
View Article and Find Full Text PDFACS Environ Au
November 2024
Department of Environmental & Resource Engineering, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Microbial electrosynthesis of HO offers an economical and eco-friendly alternative to the costly and environmentally detrimental anthraquinone process. Three-dimensional (3D) electrodes fabricated through additive manufacturing demonstrate significant advantages over carbon electrodes with two-dimensional (2D) surfaces in microbial electrosynthesis of HO. Nevertheless, the presence of oxygen-containing free acidic groups on the prototype electrode surface imparts hydrophilic properties to the electrode, which affects the efficiency of the two-electron oxygen reduction reaction for HO generation.
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