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The present study aimed to evaluate the influence of the 31C/T polymorphism on gastric inflammatory response and precancerous lesions development - atrophic gastritis (AG) and intestinal metaplasia (IM) - in patients positive for infection with functional dyspepsia (FD). The diagnosis of FD followed the Rome III criteria, and the infection was evaluated by urease test and histological examination of gastric biopsies (corpus, antrum, and incisura). The severity of chronic inflammation and inflammatory activity, as well as the presence of precancerous lesions were evaluated accordingly to the updated Sydney System. Genotyping of the -31C/T polymorphism (rs1143627) was performed by polymerase chain reaction-restriction fragment length polymorphism. A total of 303 patients positive for infection with FD were analyzed (81.8% women; mean age of 46.3 ± 12.3 years). No differences were observed in overall genotype frequencies among outcomes evaluated. However, in the dominant -31C allele model (CC+CT vs. TT), the frequency of the TT genotype was significantly higher among patients with moderate/severe chronic inflammation of the antrum than the frequency of the CC+CT genotypes (80.8% 65.2%; OR = 2.25; 95% CI = 1.23-4.24; = .005). The presence of AG and IM in the gastric mucosa of patients was of 19.5% and 19.1%, respectively. No significant association was observed concerning the frequencies of the genotypes of 31C/T polymorphism with development of precancerous lesions. In conclusion, our data suggest that genetic variants of the -31C/T polymorphism play a role in chronic inflammation of the gastric mucosa in -infected FD patients.
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| http://dx.doi.org/10.1080/08820139.2019.1710532 | DOI Listing |
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