Histoplasmosis, a fungal infection caused by , is poor prognosis once it disseminated, especially in immunocompromised patients. A 50-year-old Japanese-Brazilian male with multiple cervical lymphadenopathies was diagnosed as disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS). Anti-fungal therapy was initiated followed by anti-retroviral therapy (ART). He achieved long-term remission by treatment with voriconazole. Here we report a case of an AIDS patient with disseminated histoplasmosis who achieved long-term survival in non-endemic area.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938860PMC
http://dx.doi.org/10.1016/j.mmcr.2019.12.012DOI Listing

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Article Synopsis
  • The study explores the relationship between pancytopenia (a decrease in blood cells) and disseminated histoplasmosis, noting that this connection is rarely documented in existing literature.
  • The authors reviewed 72 cases worldwide, primarily from the Americas, finding that many patients had underlying conditions, such as HIV and haemophagocytic lymphohistiocytosis.
  • Recovery rates were relatively high at 73.6%, but significant mortality was attributed to diagnostic delays and complications, indicating that early recognition of pancytopenia may be crucial for better patient outcomes.
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Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).

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We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago.

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