Histoplasmosis, a fungal infection caused by , is poor prognosis once it disseminated, especially in immunocompromised patients. A 50-year-old Japanese-Brazilian male with multiple cervical lymphadenopathies was diagnosed as disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS). Anti-fungal therapy was initiated followed by anti-retroviral therapy (ART). He achieved long-term remission by treatment with voriconazole. Here we report a case of an AIDS patient with disseminated histoplasmosis who achieved long-term survival in non-endemic area.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938860 | PMC |
http://dx.doi.org/10.1016/j.mmcr.2019.12.012 | DOI Listing |
Infection
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Med Mycol
December 2024
UR 3738 - CICLY - Equipe Inflammation et immunité de l'épithélium respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France.
Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).
View Article and Find Full Text PDFJ Fungi (Basel)
November 2024
Department of Communicable Diseases Prevention, Control, and Elimination, Pan American Health Organization, Washington, DC 20037, USA.
In the original publication [...
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
St Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago.
View Article and Find Full Text PDFPediatr Infect Dis J
December 2024
Division of Pediatrics Infectious Diseases, Department of Pediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
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