AI Article Synopsis
- The study focused on creating a new wound dressing coating using antimicrobial silver (Ag) and antioxidant quercetin (Q) to improve wound healing.
- Researchers applied the coating to cotton gauze using a dip-coating technique and tested its effectiveness through various methods, including SEM and EDX analysis.
- Results showed that the combination of Ag and Q increased antimicrobial activity, improved wound healing rates in a mouse model, and reduced inflammation, suggesting potential benefits for advanced wound care therapies.
Article Abstract
Purpose: The aim of this study is to develop a new coating for wound dressings that is comprised of antimicrobial silver (Ag) and antioxidant flavonoid quercetin (Q).
Methods: Dip-coating was used to apply the coating on cotton gauge as a model dressing. Ag was immobilised using polydopamine as a priming and catalytic layer followed by coating of quercetin that was incorporated in a functionalized polydimethylsiloxane. The coating was investigated using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and release assay. The antimicrobial activity of quercetin and Ag was tested against (). A surgical wound model on mice was used to evaluate the effects of the coated dressing on wound healing rates and tissue histology.
Results: Ag and quercetin showed enhanced antimicrobial activity against when used in combination. Ag and quercetin were successfully immobilized onto the fibre of the dressing using the dip-coating process. The coating released Ag and quercetin over 8 days and showed strong antioxidant activity. In the wound healing model, complete wound closure was achieved in 12 days in the group receiving coated dressing and was associated with an enhancement in tissue remodelling and neo-angiogenesis and the reduction in tissue inflammation.
Conclusion: These new antimicrobial-antioxidant coatings may be promising in the development of advanced wound care therapies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926368 | PMC |
| http://dx.doi.org/10.2147/IJN.S230214 | DOI Listing |
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