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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1.
Sci Rep
January 2025
Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection. Domperidone was identified by pharmacophore-based virtual screening as a small molecule that can bind to both the viral envelope (E) and the nonstructural protein 1 (NS1) of DENV.
View Article and Find Full Text PDFAn Update on Animal Models of Alcohol-Associated Liver Disease.
Am J Pathol
January 2025
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA; Department of Internal Medicine, Division of Gastroenterology, Hepatology & Mobility, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. Electronic address:
Alcohol-associated liver disease (ALD) is a significant global health concern and a leading cause of liver disease-related deaths. However, the treatment options are limited due to the lack of animal models that accurately replicate ALD pathogenesis. An ideal ALD animal model should have pathological characteristics similar to those of human ALD, with a clear pathological process and ease of drug intervention.
View Article and Find Full Text PDFData on effect of NPSB fertilizer rates on growth and yield of carrot ( L.) varieties in Gondar district, Northwestern Ethiopia.
Data Brief
February 2025
Department of Horticulture, College of Agriculture and Environmental Sciences, Debre Markos University. Po Box: 269, Ethiopia.
Carrot ( L.) is one of the most important root crops grown worldwide and in Ethiopia. However, its production and productivity are low due to a lack of improved varieties and unbalanced fertilizer rates, among other factors.
View Article and Find Full Text PDFThe C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination.
Biochem J
January 2025
The Sun Yat-Sen University, Guangzhou, China.
The N6-methyladenine (6mA) modification is an essential epigenetic marker and plays a crucial role in processes, such as DNA repair, replication, gene expression regulation, etc. YerA from Bacillus subtilis is considered a novel class of enzymes capable of catalyzing the deamination of 6mA to produce hypoxanthine. Despite the significance of this type of enzymes in bacterial self-defense systems and potential applications as a gene-editing tool, the substrate specificity, the catalytic mechanism and the physiological function of YerA are currently unclear due to the lack of structural information.
View Article and Find Full Text PDFExperience modulates gaze behavior and the effectiveness of information pickup to overcome the inversion effect in biological motion perception.
PLoS One
January 2025
Division of Kinesiology and Health, University of Wyoming, Laramie, WY, United States of America.
The inversion effect in biological motion suggests that presenting a point-light display (PLD) in an inverted orientation impairs the observer's ability to perceive the movement, likely due to the observer's unfamiliarity with the dynamic characteristics of inverted motion. Vertical dancers (VDs), accustomed to performing and perceiving others to perform dance movements in an inverted orientation while being suspended in the air, offer a unique perspective on this phenomenon. A previous study showed that VDs were more sensitive to the artificial inversion of PLDs depicting dance movements when compared to typical and non-dancers if given sufficient dynamic information.
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