AI Article Synopsis
- Scientists found out that integrins help cells react to forces from outside.
- They discovered that syndecan-4 plays a big role in how cells change their strength when they feel tension, working together with two other receptors.
- This research shows how cells can adapt to their environment and could change our understanding of how cells respond to forces.
Article Abstract
Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via a coordinated mechanochemical signalling response that involves activation of two other receptors: epidermal growth factor receptor and β1 integrin. Tension on syndecan-4 induces cell-wide activation of the kindlin-2/β1 integrin/RhoA axis in a PI3K-dependent manner. Furthermore, syndecan-4-mediated tension at the cell-extracellular matrix interface is required for yes-associated protein activation. Extracellular tension on syndecan-4 triggers a conformational change in the cytoplasmic domain, the variable region of which is indispensable for the mechanical adaptation to force, facilitating the assembly of a syndecan-4/α-actinin/F-actin molecular scaffold at the bead adhesion. This mechanotransduction pathway for syndecan-4 should have immediate implications for the broader field of mechanobiology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260055 | PMC |
| http://dx.doi.org/10.1038/s41563-019-0567-1 | DOI Listing |
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