Since our last report on the voluntary Hungarian Twin Registry (HTR) in 2012, the number of pairs or multiplets included increased from 310 to 1044. Efforts to turn the registry into a population-based one are on the way. Nearly 128,000 twins living in Hungary (98,500 adults) will be mailed information on how to register on the new HTR website. Twins will be asked to invite their spouses and immediate family members. Meanwhile, strong cooperation through exchange programs has been developed with other foreign twin registries. Current research focuses on radiogenomics, musculoskeletal, cardiovascular and respiratory diseases, gut microbiome as well as basic molecular research and yielded new awards and further publications.
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| http://dx.doi.org/10.1017/thg.2019.100 | DOI Listing |
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The Role of Sibling Patterns in the Educational Attainment of Hungarian Twins.
Twin Res Hum Genet
August 2024
Maria Kopp Institute for Demography and Families, Budapest, Hungary.
Studies concerning twins with a sociological focus are scarce in Hungary as well as international research, although the number of twin births has increased dramatically worldwide. The raising and education of twins are tasks demanding special attention from both the family and institutions. In our study we examine these aspects, looking back from adulthood, using the narrow scope of the available data from research based on the 'Hungarostudy 2021' database ( total: 7000; twins: 106).
View Article and Find Full Text PDFThe interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study.
Psychiatry Res Neuroimaging
December 2024
Medical Imaging Centre, Semmelweis University, 1082, Budapest, Hungary. Electronic address:
Article Synopsis
- The study investigates the heritability of brain structures in the limbic system and hippocampus, focusing on twin pairs to understand genetic versus environmental influences on these areas.
- Using MRI scans of 59 healthy adult twins, researchers found that most limbic cortex and hippocampal volumes showed significant genetic heritability, whereas specific regions like the entorhinal area and CA2-CA3 were influenced more by environmental factors.
- Overall, while genetic factors play a substantial role in the size of these brain regions, some areas are notably affected by shared environmental influences, indicating a complex interplay between genetics and environment in brain structure.
Improved polygenic risk prediction in migraine-first patients.
J Headache Pain
September 2024
Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University, Nagyvarad ter 4., Budapest, 1096, Hungary.
Background: Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30-60%.
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- Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
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[Examination of breast density in breast cancer discordant twin pairs].
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Onkológiai Képalkotó és Invazív Diagnosztikai Központ, Országos Onkológiai Intézet, Budapest, Hungary.
Previous twin studies show that genetic factors are responsible for 63% of the variability in breast density. We analyzed the mammographic images of 9 discordant twin pairs for breast cancer from the population-based Hungarian Twin Registry. We measured breast density using 3D Slicer software.
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