AI Article Synopsis
- Targeted therapies like crizotinib are commonly used to treat ALK-rearranged non-small cell lung cancer (NSCLC), but adverse effects need to be closely monitored due to rapid drug developments.
- A case involved a 31-year-old woman who developed osteitis, resembling bone metastasis, after 3 months on crizotinib, showing the importance of distinguishing between side effects and cancer progression.
- This is the first documented instance of crizotinib-induced osteitis, suggesting that its action on multiple kinases may lead to unexpected complications like extensive bone inflammation.
Article Abstract
Background: Targeted therapies are a standard of care for first-line treatment of Anaplastic lymphoma kinase (ALK)-rearranged non small cell lung cancer (NSCLC). Giving the rapid pace of drug discovery and development in this area, reporting of adverse effects of ALK inhibitors is crucial. Here, we report a case of osteitis induced by an ALK inhibitor mimicking bone metastasis, a previously undescribed side effect of crizotinib.
Case Presentation: A 31-year-old woman with stage IV ALK-rearranged NSCLC presented with back pain after 3 months of crizotinib treatment. Diagnostic work-up showed osteitis on the 4th and 5th thoracic vertebrae, anterior soft tissue infiltration and epiduritis, without any sign of infection. Spinal cord decompression, histological removal and osteosynthesis were performed. Histologic examination showed necrosis with abundant peripheral neutrophils, no microorganism nor malignant cell. Symptoms and Computarized Tomography-abnormalities rapidly diseappeared after crizotinib withdrawal and did not recur after ceritinib onset.
Conclusions: This is the first report of crizotinib-induced osteitis. Crizotinib differs from other ALK inhibitors as it targets other kinases as well, which may have been responsible for the osteitis. Crizotinib can induce rapidly extensive osteitis, which can mimic tumor progression.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945627 | PMC |
| http://dx.doi.org/10.1186/s12885-019-6486-3 | DOI Listing |
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Crizotinib-induced osteitis mimicking bone metastasis in a stage IV ALK-rearranged NSCLC patient: a case report.
BMC Cancer
January 2020
Service de pneumologie, oncologie thoracique et soins intensifs respiratoires, CHU Charles Nicolle, Rouen, France.
Article Synopsis
- Targeted therapies like crizotinib are commonly used to treat ALK-rearranged non-small cell lung cancer (NSCLC), but adverse effects need to be closely monitored due to rapid drug developments.
- A case involved a 31-year-old woman who developed osteitis, resembling bone metastasis, after 3 months on crizotinib, showing the importance of distinguishing between side effects and cancer progression.
- This is the first documented instance of crizotinib-induced osteitis, suggesting that its action on multiple kinases may lead to unexpected complications like extensive bone inflammation.
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