AI Article Synopsis
- - Toxin-antitoxin systems (TASs) are important gene pairs in bacteria that play a role in various biological processes, including disease-causing abilities, but their study in specific pathogenic bacteria has been limited.
- - Using the TASmania database, researchers examined 352 bacterial genomes to identify core gene TASs (cgTASs) and accessory gene TASs (acTASs), enhancing previous studies by adding data from an additional 227 isolates.
- - They found that differences in 14 specific cgTAS alleles can distinguish the four main lineages of the bacteria, and they identified certain protein residues that likely co-evolve, indicating their significance in interactions within the TAS system.
Article Abstract
Toxin-antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in (), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania database, we focused on the known and new putative TASs in 352 genomes and identified the putative core gene TASs (cgTASs) with the Pasteur BIGSdb-Lm database and, by complementarity, the putative accessory gene TAS (acTASs). We combined the cgTASs with those of an additional 227 isolates from our previous studies containing metadata information. We discovered that the differences in 14 cgTAS alleles are sufficient to separate the four main lineages of . Analyzing these differences in more details, we uncovered potentially co-evolving residues in some pairs of proteins in cgTASs, probably essential for protein-protein interactions within the TAS complex.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020466 | PMC |
| http://dx.doi.org/10.3390/toxins12010029 | DOI Listing |
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