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Immunoglobulin D-Lambda Multiple Myeloma Initially Presenting in the Sphenoid Sinus, Orbital Apex, and Skull Base: A Systematic Review with a Case Report.
J Neurol Surg Rep
July 2024
Department of Otolaryngology-Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Article Synopsis
- Multiple myeloma (MM) initially manifesting in the sphenoid sinus and skull base is rare, with a systematic review of 34 cases highlighting the challenges of early diagnosis and treatment, particularly for the IgD-λ subtype.
- A unique case of IgD-λ MM showed symptoms like dizziness and blindness, leading to a confirmed diagnosis and a wide range of diagnostic tests, including advanced imaging and biopsies.
- The study emphasizes the importance of using CT and MRI scans for detecting bone damage, and suggests that endoscopic procedures are effective for tissue biopsies, which can improve diagnosis in asymptomatic regions like the paranasal sinuses.
Orbital Myeloma and Plasmacytoma: An Australian Study.
Ophthalmic Plast Reconstr Surg
September 2024
Save Sight Institute, Faculty of Medicine and Health, the University of Sydney, Sydney, New South Wales, Australia.
Purpose: The purpose of this study was to provide Australian data on the clinical and radiological features and outcomes in patients with orbital plasmacytomas.
Methods: Multicentre retrospective review of orbital plasmacytoma and orbital involvement in multiple myeloma (MM) from 2005 to 2022 in Australia.
Results: Twenty-one participants were identified.
Extramedullary plasmacytoma of the orbit complicating the evolution of multiple myeloma in complete remission.
Leuk Res Rep
April 2024
Hematology Department, Fattouma Bourguiba Hospital of Monastir, Avenue Farhat Hached, Monastir 5000, Tunisia.
Orbital plasmacytoma is rare and has only been reported in the context of the initial diagnosis of multiple myeloma. Moreover, isolated orbital plasmacytoma without any signs of multiple myeloma is extremely rare. We report the case of a 59-year-old female patient diagnosed with IgA Kappa multiple myeloma.
View Article and Find Full Text PDFSuccessful Treatment of Refractory Orbital Plasmacytoma with Chimeric Antigen Receptor T Cell Therapy: A Case Report and Review of the Literature.
Ophthalmic Plast Reconstr Surg
July 2024
Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, U.S.A.
Orbital plasmacytoma is a rare plasma cell tumor that may arise as an aggressive form of extramedullary multiple myeloma. Treatment modalities include surgical excision, radiation, and chemotherapy. Chimeric antigen receptor T cell therapy is currently reserved for refractory disease.
View Article and Find Full Text PDFSuperior Oblique Muscle Extramedullary Plasmacytoma in a Patient with Multiple Myeloma and a Review of Literature.
Case Rep Ophthalmol
March 2024
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: Multiple myeloma (MM), a plasma cell malignancy, is a systemic disease affecting various body organs. Plasmacytoma of bone and extramedullary disease (EMD) are presentations of MM. EMD is usually the sign of a more aggressive form of the disease.
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