AI Article Synopsis

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as crucial elements in molecular biology, influencing various biological processes like cell differentiation and tumor formation.
  • This review highlights the recent research on lncRNAs, focusing on their mechanisms and characteristics, especially concerning normal and malignant blood cell development (hematopoiesis).
  • The findings suggest that lncRNAs could be key players in gene regulation and may offer new opportunities for diagnosing and treating blood-related diseases in the future.

Article Abstract

Long noncoding RNAs (lncRNAs) have recently been discovered and are increasingly recognized as vital components of modern molecular biology. Accumulating evidence shows that lncRNAs have emerged as important mediators in diverse biological processes such as cell differentiation, pluripotency, and tumorigenesis, while the function of lncRNAs in the field of normal and malignant hematopoiesis remains to be further elucidated. Here, we widely reviewed recent advances and summarize the characteristics and basic mechanisms of lncRNAs and keep abreast of developments of lncRNAs within the field of normal and malignant hematopoiesis. Based on gene regulatory networks at different levels of lncRNAs participation, lncRNAs have been shown to regulate gene expression from epigenetics, transcription and post transcription. The expression of lncRNAs is highly cell-specific and critical for the development and activation of hematopoiesis. Moreover, we also summarized the role of lncRNAs involved in hematological malignancies in recent years. LncRNAs have been found to play an emerging role in normal and malignant hematopoiesis, which may provide novel ideas for the diagnosis and therapeutic targets of hematological diseases in the foreseeable future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046246PMC
http://dx.doi.org/10.1097/CM9.0000000000000624DOI Listing

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