Effects of Particle Size of Inhaled Corticosteroid on the Voice.

Objectives: The purpose of this study was to determine if inhaled corticosteroid (ICS) particle size influences the development of laryngitis including candida laryngitis, dysphonia, or vocalis muscle atrophy in asthmatic patients.

Study Design: Retrospective analysis.

Methods: Medical records of patients from a quaternary care laryngology practice who have asthma were reviewed retrospectively. Subjects were divided into two groups determined by the particle size of their ICS, small or standard. Each patient only used one type of inhaler. All subjects had been seen in the office for dysphonia evaluation. Statistical analysis was performed on the collected data using χ2 analysis with Yate's Correction for categorical data and a student t-test for means. A P value of less than 0.05 was considered significant.

Results: There was a significant difference in vocal fold atrophy rate between groups.

Conclusion: Routine use of standard particle size ICS is associated with more atrophy than small size ICS.