Down expression of decreases that of is associated with the lung cancer susceptibility and cigarette smoking history.

is a lncRNA transcribed from (surfactant associated protein C), a lung tissue specific gene encoding pulmonary-associated surfactant protein C (SPC) that is solely secreted by alveolar typeⅡ epithelial cells, among which the ones with might be transformed into lung adenocarcinoma cells. Caveolin-1 () is a candidate tumor suppressor gene and is vital for coping with oxidative stress induced by cigarette smoke. When comparing lung cancer tissues with their adjacent normal tissues, the expression of were decreased, especially in patients with cigarette smoking history (=0.027), and positively associated with the expression of (0.001). When comparing to A549 cells transfected with empty vector (A549-NC cells), the expression level of in A549 cells with over-expressed (A549-BMP cells) was increased along with the decreased level of HDAC2 protein. The drug sensitivity of A549-BMP cells to Doxorubicin hydrochloride (DOX) was increased; the growth and migration capability of A549-BMP cells were inhibited along with the decreased protein level of Bcl-2 and DNMT3a; the growth of tumor in nude mice injected with A549-BMP cells were inhibited, too. Furthermore, the and expression was also down-regulated in the human bronchial epithelial (16HBE) cells treated with cigarette smoke extract (CSE).