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Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries. | LitMetric

Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries.

EBioMedicine

Department of Pathology and Molecular Medicine, McMaster University, Ontario L8N 3Z5, Canada; Department of Health Research, Methods, Evidence, and Impact, Canada; Institute for Infectious Diseases Research, McMaster University Hamilton, Canada. Electronic address:

Published: January 2020

AI Article Synopsis

  • Researchers studied how genes might affect the chances of getting serious dengue fever types in different groups of people.
  • They looked at data from 7,460 people from Latin America, South Asia, and Southeast Asia to see how their genes related to the risk of dengue.
  • The study found that certain genetic factors made people significantly more likely to get the more dangerous types of dengue compared to regular dengue, and this risk was similar across different ancestry groups.

Article Abstract

Background: Genetic risk factors for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and dengue fever (DF) are limited, in particular there are sparse data on genetic risk across diverse populations.

Methods: We conducted a genome-wide association study (GWAS) in a derivation and validation sample of 7, 460 participants of Latin American, South Asian, and South East Asian ancestries. We then developed a weighted polygenic risk score (PRS) for each participant in each of the validation cohorts of the three ancestries to predict the risk of DHF/DSS compared to DF, DHF/DSS compared to controls, and, DF compared to controls.

Findings: The risk of DHF/DSS was significantly increased, odds ratio [OR] 1.84 (95%CI 1.47 to 2.31) (195 SNPs), compared to DF, fourth PRS quartile versus first quartile, in the validation cohort. The risk of DHF/DSS compared to controls was increased (OR=3.94; 95% CI 2.84 to 5.45) (278 SNPs), as was the risk of DF compared to controls (OR=1.97; 95%CI 1.63 to 2.39) (251 SNPs). Risk increased in a dose-dependent manner with increase in quartiles of PRS across comparisons. Significant associations persisted for PRS built within ancestries and applied to the same or different ancestries as well as for PRS built for one outcome (DHF/DSS or DF) and applied to the other.

Interpretation: There is a strong genetic effect that predisposes to risk of DHF/DSS and DF. The genetic risk for DHF/DSS is higher than that for DF when compared to controls, and this effect persists across multiple ancestries.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940652PMC
http://dx.doi.org/10.1016/j.ebiom.2019.11.045DOI Listing

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