Aims And Objective: Effective components and the mechanism of action of Zhichan powder for the treatment of Parkinson's disease were researched at a systematic level.
Materials And Methods: Screening of active components in Zhichan powder for the treatment of Parkinson's disease was conducted using the Traditional Chinese Medicine Systems Pharmacology database, and a medicine-target-disease network was established with computational network pharmacology.
Results: By using network pharmacology methods, we identified 18 major active components in Zhichan powder through screening, indicating a connection between chemical components of this Traditional Chinese Medicine and Parkinson's disease-related targets.
Conclusion: The medicine-target-disease system of Zhichan powder established by network pharmacology permitted visualization of clustering and differences among chemical components in this prescription, as well as the complex mechanism of molecular activities among those effective components, relevant targets, pathways, and the disease. Thus, our results provide a new perspective and method for revealing the mechanism of action of Traditional Chinese Medicine prescriptions.
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Network Pharmacology Analysis on Zhichan Powder in the Treatment of Parkinson's Disease.
Comb Chem High Throughput Screen
March 2021
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.
Aims And Objective: Effective components and the mechanism of action of Zhichan powder for the treatment of Parkinson's disease were researched at a systematic level.
Materials And Methods: Screening of active components in Zhichan powder for the treatment of Parkinson's disease was conducted using the Traditional Chinese Medicine Systems Pharmacology database, and a medicine-target-disease network was established with computational network pharmacology.
Results: By using network pharmacology methods, we identified 18 major active components in Zhichan powder through screening, indicating a connection between chemical components of this Traditional Chinese Medicine and Parkinson's disease-related targets.
Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the substantia nigra of Parkinson's disease rats.
Neural Regen Res
September 2012
Department of Biochemistry and Molecular Biology, Institute for Regenerative Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Previous studies have shown that Zhichan powder elevated immunity and suppressed oxidation in mice. Rat models of Parkinson's disease were induced by stereotaxically injecting 6-hydroxydopamine into the substantia nigra. The rat models were intragastrically treated with Zhichan powder, which is composed of milkvetch root, ginseng, bunge swallowwort root, himalayan teasel root, Magnolia officinalis, Ligustrum lucidum Ait.
View Article and Find Full Text PDFZhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats.
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Department of Radiology, Second Clinical Hospital of Jilin University, Changchun 130021, Jilin Province, China.
In this study, rat models of Parkinson's disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower.
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