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Epstein-Barr virus lytic replication and cancer.
Curr Opin Virol
December 2024
German Cancer Research Center (DKFZ) Unit D400, Heidelberg, Germany; Institut National de la Santé et de la Recherche Médicale (INSERM) mixed Unit, Heidelberg, Germany. Electronic address:
Epidemiological studies have provided strong evidence that Epstein-Barr virus (EBV) lytic replication is linked to cancer development. Evidence of abortive lytic replication in some tumors and infections with recombinant viruses incapable of lytic replication in animal models have reinforced this view. Furthermore, multiple lytic proteins have been shown to induce genetic instability, a well-characterized precancerous state.
View Article and Find Full Text PDFThe Effect of CBM1 and Linker on the Oxidase, Peroxidase and Monooxygenase Activities of AA9 LPMOs: Insight into Their Correlation with the Nature of Reductants and Crystallinity of Celluloses.
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November 2024
The Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
This study explores the effect of carbohydrate-binding module 1 (CBM1) and the linker on the function of auxiliary activity 9 (AA9) lytic polysaccharide monooxygenases (LPMOs), with a particular focus on monooxygenase activity, using different crystallinity celluloses and electron donors. The tested C1/C4-oxidizing AA9 LPMOs exhibited higher oxidase and peroxidase activities compared to those of the C4-oxidizing AA9 LPMOs. While the presence of CBM1 promoted cellulose-binding affinity, it reduced the oxidase activity of modular AA9 LPMOs.
View Article and Find Full Text PDFIntegrating Bacteriophage onto the Magnetic Nanozyme for Effective Enrichment and Colorimetric Detection of in Powdered Infant Formula.
Foods
November 2024
School of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
is a dangerous pathogen easily found in powdered infant formula (PIF), causing severe infections and even death in infants. Herein, a bacteriophage-immobilized magnetic nanozyme (FeO@EspYZU13) was prepared for detection. Bacteriophage EspYZU13 isolated and identified by our group exhibits specific lytic capacity.
View Article and Find Full Text PDFTransformation of a Testicular Teratoma to an Aggressive Primitive Neuroectodermal Tumor.
Cureus
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Pathology and Laboratory Medicine, University of California Davis Health System, Sacramento, USA.
We present a case of a 36-year-old male found to have a nonseminomatous germ cell tumor (NSGCT) with alpha-fetoprotein levels (AFP) of 737.9 ng/mL and beta-human chorionic gonadotropin (β-HCG) of 692 IU/mL. Pathology analysis after left orchiectomy showed a mixed germ cell tumor with 20% embryonal carcinoma, 20% yolk sac tumor, and 60% teratoma.
View Article and Find Full Text PDFComparing enzymatic post-treatments by endoglucanase (EG) and lytic polysaccharide monooxygenase (LPMO) on microfibrillated cellulose (MFC) to enhance cellulose film fabrication.
Carbohydr Polym
February 2025
Forest Product Biotechnology/Bioenergy Group, Department of Wood Science, University of British Columbia, 2424 Main Mall, Vancouver, V6T 1Z4, Canada. Electronic address:
Cellulose is the world's most abundant natural polymer and it can be used as a substitute for fossil derived products. The work described here evaluated the use of mono-component enzyme treatment, using endoglucanase (EG) and lytic polysaccharide monooxygenase (LPMO), to improve the properties of micro-fibrillated cellulose (MFC) produced from mechanically refined kraft pulp. Endoglucanase treatment of the pulp significantly reduced the degree of polymerization (DP) of the cellulose by promoting fiber cutting.
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