Background: Trichoscopy, in combination with image analysis software, is a readily available, efficient diagnostic tool for assessing hair follicle parameters of people in vivo. Systems designed for use in human dermatology must be evaluated and validated with animal skin/hair before they can be used for veterinary applications.
Objectives: To evaluate the use of a commercial software package for image analysis of canine hair follicles and to define hair follicle parameters.
Animals: Thirteen client-owned healthy dogs.
Methods: Trichoscopic images at x20 magnification were obtained from three shaved body sites (left dorsal head, left thorax, left flank) over a five day period, then analyzed by the software.
Results: The image analysis software was able to identify microscopic changes in hair length on a daily basis, calculating a mean hair growth rate of 0.065 mm/day. Each of the three body sites had consistent hair growth rates across all days. Anagen and telogen percentages were consistent at each body site by Day 2 (48 h post-clipping). Data for mean hair thickness, and primary and secondary hair percentages also are reported.
Conclusions: Although it provides less useful data for canine hair coats than for human scalp hair, the system evaluated provides an easy, noninvasive, rapid means for assessing several important canine hair follicle parameters: daily hair growth rates, anagen and telogen percentages, primary and secondary hair percentages, and mean hair thickness. This diagnostic tool could serve to establish breed-specific hair coat standards, evaluating hair follicle changes in various canine alopecic conditions and monitoring coat-promoting treatments in dogs.
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http://dx.doi.org/10.1111/vde.12836 | DOI Listing |
Int J Pharm
January 2025
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, PR China. Electronic address:
Traditional wound care preparations frequently face challenges such as complex care protocols, poor patient compliance, limited skin permeability, lack of aesthetics, and inconvenience, in addition to the risk of bacterial infection. We developed a spray film preparation containing nanocellulose and L-serine modified nanosilver, capable of rapidly forming a transparent film on the skin within minutes of application. The incorporation of nanocellulose imparted protective, moisturizing, and breathable properties to the film, allowing for easy removal after use.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China; Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou, Jiangsu 225009, China. Electronic address:
Decorin (DCN) is a member of the small leucine-rich proteoglycan family within the extracellular matrix, playing a role in the growth and development of hair follicle (HF). Exosomes serve as significant mediators of intercellular communication and are involved in the cyclic regeneration of HF. Exosomes derived from dermal papilla cells (DPC-Exos) are essential for the cycling and regrowth of HF.
View Article and Find Full Text PDFPLoS One
January 2025
School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Skin and hair development is regulated by multitude of programs of activation and silencing of gene expression to maintain normal skin and hair follicle (HF) development, homeostasis, and cycling. Here, we have identified E74-like factor 5 (Elf5) transcription factor, as a novel regulator of keratinocyte proliferation and differentiation processes in skin. Expression analysis has revealed that Elf5 expression was localised and elevated in stem/progenitor cell populations of both the epidermis (basal and suprabasal) and in HF bulge and hair germ stem cell (SCs) compartments during skin and hair development and cycling.
View Article and Find Full Text PDFACS Nano
January 2025
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200092, P. R. China.
Despite significant progress in skin wound healing, it is still a challenge to construct multifunctional bioactive dressings based on a highly aligned protein fiber coated hydrogel matrix for antifibrosis skin wound regeneration that is indistinguishable to native skin. In this study, a "dual-wheel-driven" strategy is adopted to modify the surface of methacrylated gelatin (GelMA) hydrogel with highly aligned magnetic nanocomposites-protein fiber assemblies (MPF) consisting of photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen (Fg) complexes as the building blocks. Whole-phase healing properties of the modified hydrogel dressing, GelMA-MPF (GMPF), stem from the integration of Fg protein with RGD peptide activity decorated on the surface of the antibacterial magnetic nanoactuator, facilitating facile and reproducible dressing preparation by self-assembly and involving biochemical, morphological, and biophysical cues.
View Article and Find Full Text PDFJ Med Food
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Millions of men and women suffer from alopecia, especially androgenic alopecia (AGA), which is considered the most common form of hair loss. The available treatments for hair loss include multiple approaches, with the most popular being synthetic drugs including minoxidil and finasteride, in addition to natural products. However, synthetic drugs have shown many undesirable side effects, on the contrary, the specifications of the commonly used natural drugs have not been reported in most of the previous studies, despite the high market preference for them.
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