AI Article Synopsis
- - The study investigates in situ follicular neoplasm (ISFN), a rare condition previously seen as a precursor to follicular lymphoma, focusing on its features in Japan based on 19 biopsy samples.
- - Two types of ISFN were identified: one with strong BCL-2 positivity and translocation, and another resembling follicular lymphoma without obvious translocation.
- - Analysis revealed a significant occurrence of ISFN alongside other lymphomas, but molecular findings indicated that ISFN and follicular lymphoma lesions in the same lymph node exhibit different clonality.
Article Abstract
This study aims to investigate the clinicopathological features of in situ follicular neoplasm (ISFN) in Japan. ISFN is a rare condition formerly considered as an early precursor of follicular lymphoma (FL). This is a first original report of ISFN from Asian country. We reviewed 19 biopsy samples of ISFN. ISFNs were categorized into two groups: (1) ISFN, consisting of ISFN with strong positivity for BCL-2 immunohistochemical staining (IHC), and obvious translocation of BCL-2; and (2) ISFN-like FL, featuring cases without obvious translocation but having morphological features and characteristic IHC findings of ISFN. As control, we adopted obvious FL. For some cases showing coexisting ISFN and FL lesions in the same lymph node, we could conduct further clonality analysis for each lesion. Nine of the 19 cases of ISFN coexisted with FL or had a history of overt B- or T-cell lymphoma including FL. Statistical comparison among ISFN-like FL and FL showed no significant differences in pathological features. Molecular analysis suggested that ISFN lesion and FL lesion in the same lymph node each have a different clonality. ISFN coexists or associates with other overt lymphomas frequently.
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| http://dx.doi.org/10.1007/s00277-019-03841-5 | DOI Listing |
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