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Preservation of brain metabolism in recently diagnosed Parkinson's impulse control disorders. | LitMetric

AI Article Synopsis

  • Impulse control disorders (ICDs) are common in Parkinson's disease (PD) treatment and can disrupt patients' lives, but their brain metabolism effects are less understood.* -
  • A study was conducted using F-FDG-PET scans to compare PD patients recently diagnosed with ICD to those without, as well as to healthy controls, revealing differences in brain glucose metabolism.* -
  • Findings indicate that PD patients with ICD have higher brain glucose metabolism in key areas compared to those without ICD, suggesting that better preserved brain metabolism may play a role in the development of ICD.*

Article Abstract

Background: Impulse control disorders (ICD) are a common and disrupting complication of Parkinson's disease (PD) treatment. Although their relationship with dopaminergic activity is well studied, their brain metabolic correlates are mostly unknown.

Methods: In this work we studied brain metabolism using brain F-FDG-PET. We performed a case-control study nested within a cohort of PD patients free of ICD at baseline to compare ICD patients right after ICD diagnosis and prior to any treatment modification with matched ICD-free patients. We also compared both PD groups with healthy controls.

Results: When compared with ICD-free PD patients, PD patients with recently diagnosed ICD showed higher glucose metabolism in widespread areas comprising prefrontal cortices, both amygdalae and default mode network hubs (p < 0.05, corrected). When compared to healthy controls, they did not show hypermetabolism, and the only hypometabolic region was the right caudate. In turn, ICD-free patients showed diffuse hypometabolism when compared to healthy controls.

Conclusion: Our results suggest brain metabolism is more preserved in PD patients with ICD than patients without ICD. This metabolic preservation could be related to ICD development.

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Source
http://dx.doi.org/10.1007/s00259-019-04664-2DOI Listing

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