AI Article Synopsis
Article Abstract
Clinical judgement studies are essential for recognising the causal relation of a medication with adverse drug reactions (ADRs). Traditionally, these studies are conducted via expert manual chart review. By contrast, we propose an end-to-end deep learning question answering model to automatically infer such causal relations. Our proposed model identifies the causal relation by answering a subset of Naranjo questionnaire Naranjo et al. (1981) from electronic health records. It employs multi-level attention layers along with local and global context while answering these questions. Our proposed model achieves a macroweighted F-score of 0.4598 - 0.5142 across the selected questions and an overall F-score of 0.5011. We also did an ablation study to validate the importance of local and global context for the model.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939641 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Memory stem CD8T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance.
Front Cell Infect Microbiol
December 2024
Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Human immunodeficiency Virus (HIV) and () co-infection presents a significant public health challenge worldwide. Comprehensive assessment of the immune response in HIV/ co-infection is complex and challenging. CD8T cells play a pivotal role in the adaptive immune response to both HIV and .
View Article and Find Full Text PDFM-mode ultrasound evaluation of lateral abdominal muscle postural response to load: an exploratory study.
J Ultrason
December 2024
Motion Analysis Laboratory, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
Aim: There is a need to evaluate the tissue deformation index of lateral abdominal muscles using M-mode ultrasound in a cohort of healthy subjects to establish a convenient reference point for clinical reasoning in patients. The aim of the study was to assess differences in the tissue deformation index between individual lateral abdominal muscles regardless of body side, compare these differences in the tissue deformation index on the right and left sides of the body, and evaluate side-to-side differences in the tissue deformation index within individual lateral abdominal muscles.
Material And Methods: In a group of 126 healthy volunteers (59 females), the postural response of lateral abdominal muscles to external perturbation in the form of rapid arm abduction with load was recorded on both sides of the body, and the tissue deformation index was calculated.
Neural correlates of audiovisual integration in schizophrenia - an ERP study.
Front Psychiatry
December 2024
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Introduction: Multisensory integration (MSI) enhances perception by combining information from different sensory modalities. In schizophrenia, individuals often exhibit impaired audiovisual processing, resulting in broader temporal binding windows (TBWs) which appear to be associated with symptom severity. Since the underlying mechanisms of these aberrations are not yet fully understood, the present study aims to investigate multisensory processing in schizophrenia in more detail.
View Article and Find Full Text PDFNeuraxial biomechanics, fluid dynamics, and myodural regulation: rethinking management of hypermobility and CNS disorders.
Front Neurol
December 2024
Neuromuscular Imaging Research Lab, The Kolling Institute, North Sydney Local Health District, St Leonards, NSW, Australia.
Individuals with joint hypermobility and the Ehlers-Danlos Syndromes (EDS) are disproportionately affected by neuraxial dysfunction and Central Nervous System (CNS) disorders: such as Spontaneous Intracranial Hypotension (SIH) due to spinal cerebrospinal fluid (CSF) leaks, Upper Cervical Instability (UCI; including craniocervical or atlantoaxial instability (CCI/AAI)), Occult Tethered Cord Syndrome (TCS), Chiari Malformation (CM) and Idiopathic Intracranial Hypertension (IIH). The neuraxis comprises the parts of the nervous system (brain, nerves, spinal cord) along the craniospinal axis of the body. Neuraxial tissue includes all tissue structures that comprise, support, sheath, and connect along the neuraxis and peripheral nerves.
View Article and Find Full Text PDF[Expression and clinical significance of USP20 in oral squamous cell carcinoma].
Shanghai Kou Qiang Yi Xue
October 2024
Department of Maxillofacial Surgery, Jiamusi University Affiliated Stomatological Hospital. Jiamusi 154004, Heilongjiang Province, China. E-mail:
Purpose: To investigate the expression of ubiquitin specific protease 20 (USP20) in oral squamous cell carcinoma (OSCC) and its correlation with clinicopathological parameters.
Methods: OSCC samples and paired paracancerous samples were screened from the TCGA database for differential expression analysis and paired differential analysis. Immunohistochemical staining was used to detect the expression level of USP20 in OSCC tissue, paracancerous tissues and normal tissues.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!