Transcriptome changes induced by in cervical cancer cells .

Runt-related transcription factor 3 () is a member of Runt domain family that is known to play key roles in various different types of tumor. It was recently demonstrated that may also be associated with cervical cancer. The aim of the present study was to investigate the potential association between transcriptome changes and expression in cervical cancer. A overexpression model was constructed using cervical cancer cell lines by plasmid transfection. It was demonstrated that the upregulated expression of inhibited proliferation of cervical cancer cell lines, particularly SiHa cells, and was associated with the expression of the and genes. In addition, it was revealed that the and pathways may also be affected by . Therefore, the expression of the gene may be involved in the occurrence and progression of cervical cancer.