AI Article Synopsis
- White diseases refer to various conditions characterized by a reduction in skin and eye pigmentation due to decreased melanin production.
- Melanin levels are influenced by the number and size of melanosomes produced by melanocytes located in the skin and eyes.
- Examples of white diseases include common conditions like albinism and vitiligo, as well as rarer ones like white hand syndrome and Degos disease.
Article Abstract
White diseases are a heterogenous group characterized by hypopigmentation or depigmentation. Skin and eye color are determined by the number and size of melanosomes present. Melanin is produced by melanosomes in the melanocytes present within the epidermis of the skin, uvea, and retinal pigmented epithelium (RPE). Conditions altering the number of melanocytes or concentration of melanin result in a lack of pigmentation, appearing as "white diseases" ranging from the well-known albinism and vitiligo to more esoteric white hand syndrome and Degos disease.
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| http://dx.doi.org/10.1016/j.clindermatol.2019.07.018 | DOI Listing |
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