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Complement C3d enables cell-mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells.
Proc Natl Acad Sci U S A
December 2024
Department of Surgery, University of Michigan, Ann Arbor, MI 48109.
Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell-mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a previously unknown function for intracellular C3d, we found that C3d engaged T cell responses against malignant PC in the bone marrow of mice that had developed multiple myeloma spontaneously.
View Article and Find Full Text PDFExosomes in stroke management: a promising paradigm shift in stroke therapy.
Neural Regen Res
December 2024
Department of Neurosurgery, The First Hospital Affiliated to Army Medical University, Chongqing, China.
Effective treatment methods for stroke, a common cerebrovascular disease with a high mortality rate, are still being sought. Exosome therapy, a form of acellular therapy, has demonstrated promising efficacy in various diseases in animal models; however, there is currently insufficient evidence to guide the clinical application of exosome in patients with stroke. This article reviews the progress of exosome applications in stroke treatment.
View Article and Find Full Text PDFRepair of Osteochondral Defect with Acellular Cartilage Matrix and Thermosensitive Hydrogel Scaffold.
Tissue Eng Part A
December 2024
Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
In the present study, acellular cartilage matrix (ACM) was modified with poly-l-lysine/hyaluronic acid (PLL/HA) multilayers via detergent-enzyme chemical digestion and layer-by-layer self-assembly technology. This modified ACM was then loaded with Transforming Growth Factor Beta 3 (TGF-β3) and incorporated into a thermosensitive hydrogel (TH) to create a HA/PLL-ACM/TH composite scaffold with sustained-release function. This study aimed to evaluate the efficacy of this novel composite scaffold in promoting chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and facilitating osteochondral defect repair.
View Article and Find Full Text PDFEngineered biomimetic nanovesicles-laden multifunctional hydrogel enhances targeted therapy of diabetic wound.
Mater Today Bio
December 2024
Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong, University of Science and Technology, Wuhan, 430022, China.
Article Synopsis
- Angiogenesis is crucial for healing diabetic wounds, and endothelial progenitor cell-derived extracellular vesicles (EPC-EVs) can enhance this process, but their use is limited by low yield and targeting issues.
- The study developed biomimetic nanovesicles (EPC-NV) from EPCs and modified them with cRGD peptides (mEPC-NV) for better targeting of endothelial cells.
- A dual hydrogel network was created that combined an acellular dermal matrix with light-cured gelatin to sustainably release mEPC-NV while providing antioxidant and antibacterial properties, making it a promising approach for diabetic wound treatment.
Impact of the US Maternal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis (Tdap) Vaccination Program on Preventing Pertussis in Infants 2 to <6 Months of Age: A Case-Control Evaluation.
Open Forum Infect Dis
November 2024
Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia, USA.
Background: To protect infants aged <2 months against pertussis, the United States recommends Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccination during each pregnancy. Data are limited on the strategy's effectiveness against pertussis in infants aged ≥2 months.
Methods: Pertussis case infants aged 2 to <6 months with cough onset between 1 January 2011 and 31 December 2014 were identified in 6 US states.
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