To observe and analyze the therapeutic efficacy of minocycline hydrochloride ointment in the treatment of early peri-implantitis. A total of 180 patients with early peri-implantitis and treated at our hospital were enrolled. The patients were divided into control group and research group, with 90 patients in each group. Of those, patients in the research group were treated with minocycline hydrochloride ointment, while 10% of iodine was placed around the teeth in patients of the control group. The therapeutic efficacy was observed and compared between both groups. By comparing the plaque index of both groups after treatment, results showed that the improvement of the research group was obviously better than that of the control group (p<0.05). By comparing the probing depth and sulcus bleeding index, results showed that the situation of the research group was significantly superior than that of the control group (p<0.05). Application of minocycline hydrochloride ointment in the treatment of early peri-implantitis could significantly improve the therapeutic efficacy.
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