AI Article Synopsis
- Steroid usage has increased due to their therapeutic benefits, but severe side effects necessitate the search for safer alternatives.
- Researchers focused on creating sugar derivatives of nandrolone and testosterone to test their bioactivities and discovered that modifying these steroids with glucose improved cell viability and reduced cytotoxicity in certain cell lines.
- The study found that these derivatives not only enhanced neuron protection but also led to increased cellular ATP levels, suggesting potential for safer steroid treatments.
Article Abstract
The application of steroids has steadily increased thanks to their therapeutic effects. However, alternatives are required due their severe side effects; thus, studies on the activities of steroid derivatives are underway. Sugar derivatives of nandrolone, which is used to treat breast cancer, as well as cortisone and prednisone, which reduce inflammation, pain, and edema, are unknown. We linked O-glucose to nandrolone and testosterone using UDP-glucosyltransferase (UGT-1) and, then, tested their bioactivities in vitro. Analysis by NMR showed that the derivatives were 17β-nandrolone β-D-glucose and 17β-testosterone β-D-glucose, respectively. The viability was higher and cytotoxicity was evident in PC12 cells incubated with rotenone and, testosterone derivatives, compared to the controls. SH-SY5Y cells incubated with HO and nandrolone derivatives remained viable and cytotoxicity was attenuated. Both derivatives enhanced neuronal protective effects and increased the amounts of cellular ATP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728329 | PMC |
| http://dx.doi.org/10.4014/jmb.1911.11057 | DOI Listing |
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