Quantitative dynamic MRI acquisitions have the potential to diagnose diffuse diseases in conjunction with functional abnormalities. However, their resolutions are limited due to the long acquisition time. Such datasets are multi-dimensional, exhibiting interactions between ≥ 4 dimensions, which cannot be easily identified using sparsity or low-rank matrix methods. Hence, low-rank tensors are a natural fit to model such data. But in the presence of multitude of different tissue types in the field-of-view, it is difficult to find an appropriate value of tensor rank, which avoids under- or over-regularization. In this work, we propose a locally low-rank tensor regularization approach to enable high-resolution quantitative dynamic MRI. We show this approach successfully enables dynamic mapping at high spatio-temporal resolutions.
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http://dx.doi.org/10.1109/CAMSAP.2017.8313075 | DOI Listing |
Phys Rev Lett
December 2024
MSC, CNRS, Université Paris Cité, UMR 7057, F-75013 Paris, France.
We report on the dynamics of a soliton propagating on the surface of a fluid in a 4-m-long canal with a random or periodic bottom topography. Using a full space-and-time resolved wave field measurement, we evidence, for the first time experimentally, how the soliton is affected by the disorder, in the context of Anderson localization, and how localization depends on nonlinearity. For weak soliton amplitudes, the localization length is found in quantitative agreement with a linear shallow-water theory.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Importance: Obesity, a chronic disease with escalating global prevalence, poses considerable health risks. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), including liraglutide, semaglutide, and tirzepatide, have demonstrated efficacy for weight loss in clinical trials. The paradigm shift in the approach to obesity management drugs (OMDs) may offer an opportunity to examine online search activity and prescription trends.
View Article and Find Full Text PDFMol Biol Cell
January 2025
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147 USA.
The endo-lysosomal system plays a crucial role in maintaining cellular homeostasis and promoting organism fitness. The pH of its acidic compartments is a crucial parameter for proper function, and it is dynamically influenced by both intracellular and environmental factors. Here, we present a method based on fluorescence lifetime imaging microscopy (FLIM) for quantitatively analyzing the pH profiles of acidic endolysosomal compartments in diverse types of primary mammalian cells and in live organism .
View Article and Find Full Text PDFMov Disord Clin Pract
January 2025
Department of Computer Science, University of Verona, Verona, Italy.
Background: Axial postural abnormalities (APAs) are frequent and disabling axial symptoms of Parkinson's disease (PD). Image-based measurement is considered the gold standard but may not accurately detect the true severity of APAs because these symptoms can appear or get worse under dynamic conditions.
Objective: The aim was to evaluate quantitative changes in APAs degree during prolonged standing and walking in both single- and dual-task conditions (motor + cognitive).
Med Phys
January 2025
Deparment of Radiation Oncology, Duke University, Durham, North Carolina, USA.
Background: Stereotactic radiosurgery (SRS) is widely used for managing brain metastases (BMs), but an adverse effect, radionecrosis, complicates post-SRS management. Differentiating radionecrosis from tumor recurrence non-invasively remains a major clinical challenge, as conventional imaging techniques often necessitate surgical biopsy for accurate diagnosis. Machine learning and deep learning models have shown potential in distinguishing radionecrosis from tumor recurrence.
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