AI Article Synopsis
- The study identifies 11 new triterpenoids, called antcamphorols A-K, along with 10 known ones, separated from a specially cultured medicinal mushroom.
- One unique compound, featuring a specific C lanostane structure, was characterized using various analytical methods like NMR and X-ray diffraction.
- Some of the new compounds showed promising abilities to scavenge reactive oxygen species and moderate cytotoxic effects against specific human cancer cell lines.
Article Abstract
is a rare and valuable medicinal mushroom. In this work, 11 new triterpenoids, namely, antcamphorols A-K (-), together with 10 known triterpenoids, -, were isolated from dish-cultured . Compound is an unprecedented C lanostane-type triterpenoid featuring a methyl group at C-15 and a C-21-O-C-24 tetrahydropyran ring at C-17. Compounds - are ergostane-type triterpenoids, and they include two pairs of norergostanes -. The structures of the new compounds were identified by NMR, 2D NMR, and HRESIMS data analyses. The absolute configurations of and were defined by X-ray diffraction data, and the absolute configuration at C-25 of was determined by the modified Mosher's method. Compounds , , , , and showed significant ROS scavenging activities (63.9-70.5% at 20 μM) in high-glucose-induced HUVECs. Compounds and exhibited moderate cytotoxic activities against U251 (IC, 9.2 μM) and MCF-7 (IC, 8.1 μM) human cancer cell lines, respectively.
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| http://dx.doi.org/10.1021/acs.jnatprod.9b00580 | DOI Listing |
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Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from .
J Nat Prod
January 2020
State Key Laboratory of Natural and Biomimetic Drugs & Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, School of Pharmaceutical Sciences , Peking University, 38 Xueyuan Road , Beijing 100191 , People's Republic of China.
Article Synopsis
- The study identifies 11 new triterpenoids, called antcamphorols A-K, along with 10 known ones, separated from a specially cultured medicinal mushroom.
- One unique compound, featuring a specific C lanostane structure, was characterized using various analytical methods like NMR and X-ray diffraction.
- Some of the new compounds showed promising abilities to scavenge reactive oxygen species and moderate cytotoxic effects against specific human cancer cell lines.
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