AI Article Synopsis
- The study investigates how long-term levels of hemoglobin A1c, a diabetes risk factor, affect cognition in younger older adults, particularly those around 70 years old.
- Results indicate that higher average hemoglobin A1c over time significantly relates to overall cognition and attention but does not impact language/executive function or memory.
- The findings support the Protected Survivor Model, highlighting that some individuals maintain good cognitive function despite sustained high-risk factors, which may inform future protective strategies.
Article Abstract
Introduction: Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration.
Methods: The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 "young-old" veterans (mean age = 70) with type 2 diabetes.
Results: The predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory.
Discussion: Findings extend the Protected Survivor Model to a "young-old" sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926347 | PMC |
| http://dx.doi.org/10.1016/j.trci.2019.11.009 | DOI Listing |
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