Levofloxacin is a fluoroquinolone antibiotic commonly used to treat a wide range of bacterial infections. It is normally well tolerated with the most common side effect being gastrointestinal distress. Severe side effects including neuropsychiatric symptoms are rare but have been observed even in patients who lack risk factors or are otherwise healthy. Healthcare providers should be aware of these effects and consider transitioning to other antibiotics in patients who develop psychosis or other neuropsychiatric symptoms after initiating this medication. Symptoms rapidly improve after discontinuation of the drug, so prompt recognition can reduce morbidity and mortality. We report a case of levofloxacin-induced psychosis in a young healthy female patient.
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Levofloxacin-induced Psychosis in a Young Healthy Patient.
Cureus
November 2019
Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, USA.
Levofloxacin is a fluoroquinolone antibiotic commonly used to treat a wide range of bacterial infections. It is normally well tolerated with the most common side effect being gastrointestinal distress. Severe side effects including neuropsychiatric symptoms are rare but have been observed even in patients who lack risk factors or are otherwise healthy.
View Article and Find Full Text PDFMetronidazole- and levofloxacin-induced psychotic disorders in chronic kidney patient.
Eur J Hosp Pharm
November 2019
Department of Pharmacy, Faculty of Medicine, University of Nis, Nis, Serbia.
We present a case which reports the occurrence of psychotic disorders after metronidazole and levofloxacin therapy in a chronic kidney patient while being treated for enterocolitis and urinary infection. A 48-year-old female was admitted to a hospital for the placement of a peritoneal dialysis catheter due to indicated peritoneal dialysis. During admission, symptoms of enterocolitis and urinary infection had occurred, so metronidazole and levofloxacin were introduced into therapy, respectively.
View Article and Find Full Text PDFLevofloxacin-induced tactile hallucination and acute anxiety reaction.
Indian J Pharmacol
December 2019
Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Fluoroquinolones are the commonly used antimicrobials in the treatment of urinary tract infection, bacterial diarrhea, and infections of soft tissue, bone, and joints. They may cause adverse effects ranging from gastrointestinal disturbances, headache, insomnia, and cutaneous reactions. Their rare adverse effects include phototoxicity, cardiotoxicity, arthropathy, and tendinitis.
View Article and Find Full Text PDFLeave the levofloxacin? A case report of levofloxacin-induced psychosis.
Am J Emerg Med
August 2018
Department of Pharmacy, Loyola University Medical Center, United States; Department of Emergency Medicine, Loyola University Medical Center, United States. Electronic address:
Fluoroquinolones, including levofloxacin, exhibit desirable antimicrobial characteristics, including broad spectrum of activity and excellent bioavailability. This widely prescribed class of antibiotics has come under scrutiny due to a new black box warning of adverse reactions. Central nervous system effects have been sparsely described in previous literature.
View Article and Find Full Text PDFLevofloxacin-induced delirium in a patient suffering from schizoaffective disorder and multiple sclerosis.
Curr Drug Saf
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Pharmacy Service. Red de Salud Mental de Araba, C/alava 43, 01006 Vitoria-Gasteiz. Alava. Spain.
Levofloxacin induced psychiatric adverse effects are rare, although they can be serious. There are just five cases of fluoroquinolone-induced delirium published in the medical literature. To our best knowledge, none of them occurred in psychotic patients.
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