[This corrects the article DOI: 10.1186/s40104-019-0390-1.].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915873PMC
http://dx.doi.org/10.1186/s40104-019-0415-9DOI Listing

Publication Analysis

Top Keywords

correction high
4
high survival
4
survival rate
4
rate sheep
4
sheep produced
4
produced blastocysts
4
blastocysts vitrified
4
vitrified method
4
method device
4
device [this
4

Similar Publications

Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.

PLoS Biol

January 2025

Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.

Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed. In this study, we utilized virtual screening to search for drug-like molecules that bind to the orthosteric site of rod opsin and improve its folding and trafficking.

View Article and Find Full Text PDF

Background And Objective: Neurofibromatosis-1 (NF1) dystrophic scoliosis is a challenging disease to manage surgically, with multiplanar curves progressing rapidly and unpredictably. Conservative management with bracing is often unsuccessful, and many patients necessitate instrumented fusion to halt progression of their curves. In rare cases, patients can present with spontaneous vertebral subluxation, significantly complicating the surgical management of this already complex disease process.

View Article and Find Full Text PDF

[Infrequent association of OEIS complex with a diaphragmatic defect].

Andes Pediatr

August 2023

Programa Madre Canguro /Alto riesgo neonatal Subred Sur-UMHES-MEISSEN, Bogotá, Colombia.

Unlabelled: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare entity that presents abdominal wall defects, entails high morbidity and mortality, and requires multidisciplinary management.

Objective: To describe a case with an unusual association between OEIS complex and diaphragmatic hernia and to discuss its pathogenesis and possible association with other midline malformations.

Clinical Case: A preterm female newborn of 33 weeks of gestational age, with prenatal diagnosis of giant omphalocele that, at birth, presented intact amnion coverture containing the entire liver and some bowel loops, open bladder exstrophy and exposed urethral orifices; uterus didelphys, no palpable gonads, and concurrent imaging findings of pelvic soft tissue extrusion, left diaphragmatic hernia (Bochdalek), multiple bone defects, myelomeningocele, and myelocystocele.

View Article and Find Full Text PDF

High-level multireference configuration interaction plus Davidson correction (MRCI + Q) calculation method was employed to determine the potential energy curves (PECs) of 10 Λ-S states, which come from the first and second dissociation channels of the SbP molecule, as well as 34 Ω states considering the spin-orbit coupling (SOC) effect. By solving the Schrödinger equation for nuclear motion, spectroscopic constants for the ground state XΣ and low-lying excited states were obtained and compared with experimental data. The excellent agreement indicates the reliability of our calculations.

View Article and Find Full Text PDF

Mitigating matrix effects in oil and gas wastewater analysis: LC-MS/MS method for ethanolamines.

Environ Sci Process Impacts

January 2025

Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Parsons Laboratory, 15 Vassar Street, Cambridge, Massachusetts 02139, USA.

The high salinity and organic content in oil and gas wastewaters can cause ion suppression during liquid chromatography mass spectrometry (LC/MS) analysis, diminishing the sensitivity and accuracy of measurements in available methods. This suppression is severe for low molecular weight organic compounds such as ethanolamines (, monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), -methyldiethanolamine (MDEA), and ,-ethyldiethanolamine (EDEA)). Here, we deployed solid phase extraction (SPE), mixed-mode LC, triple quadrupole MS with positive electrospray ionization (ESI), and a suite of stable isotope standards (, one per target compound) to correct for ion suppression by salts and organic matter, SPE losses, and instrument variability.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!