AI Article Synopsis
- The study explored the use of liposomes (DPPA and DPPC) to enhance the effectiveness of antioxidant compounds like vitamin C (hydrophilic) and vitamin E (lipophilic) in normal MDCK and tumor Jurkat T cells.
- The effectiveness of vitamins C, E, and their combination with these liposomes was found to be influenced by how well the liposomes integrate with the cell membranes and release the vitamins.
- The findings suggest that these liposomes could selectively regulate antioxidant activity, which is significant for developing targeted antitumor therapies and protective agents for healthy tissues during radiotherapy.
Article Abstract
In order to assess the possibility of using liposomes to stabilize various antioxidant compounds, we investigated the effect of liposomes (1,2-palmitoyl-phosphatidic acid (DPPA) and dipalmitoylphosphatidylcholine (DPPC)) on the effectiveness of antioxidants, hydrophilic vitamin C and lipophilic vitamin E, in model systems of normal epithelial MDCK cells and tumor Jurkat T cells. The effect of vitamins C, E and (C + E) in combination with DPPC and DPPA liposomes on Jurkat and MDCK cells depends on the dissolution or integration of these liposomes with hydrophobic sections of the cellular membrane, as well as the subsequent release of vitamins from liposomes. Based on the results of the study, it can be concluded that the studied liposomes can modulate the effects of C and E vitamins on normal and tumor cells. These data can be used to study the possible selective regulation of the activity of various hydrophobic and hydrophilic antioxidants on normal and tumor cells, which is especially important for creating antitumor drugs, as well as effective radioprotectors that protect healthy tissues from radiation damage during radiotherapy.
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