THE STATE OF PROOXIDANT-ANTIOXIDANT BALANCE IN PROSTATE GLAND OF RATS WITH CRYOTRAUMA AND ITS CORRECTION WITH DRUGS OF NATURAL ORIGIN.

The article deals with evaluation of the prooxidant-antioxidant balance in the prostate gland of rats with prostate cryotrauma caused with the help of Wartner® on the basis of biochemical studies results. The restored glutathione, lipid hydroperoxides, diene conjugates, TBA products were investigated in the prostate homogenate, together with the state of sperm according to the following characteristics: quantity, pathological forms, motility and time of its preservation. Correction was performed using the following drugs: Chondroitin sulfate, Tribestan, Chondroitin sulfate in combination with Tribestan, Prostoplant forte and Bioglobin-U. The obtained results showed that the prostate cryotrauma in rats caused by Wartner® was characterized by intensification of lipid peroxidation processes and reduced antioxidant protection, which negatively affected the sperm. All the studied drugs had a normalizing effect on the processes of liperoxidation and the state of sperm. However, the most pronounced positive effect was obtained when using Chondroitin sulfate during prostate cryotrauma in rats.