AI Article Synopsis
- The cell wall of fungi is crucial for their infection process, acting as the first contact point with the host's immune system.
- Various molecules in the cell wall, like chitin and glucans, serve as antigens that trigger immune responses while aiding in infection establishment.
- Understanding how the immune system detects these fungal antigens can lead to better diagnostic tools and treatments for fungal infections.
Article Abstract
By being the first point of contact of the fungus with the host, the cell wall plays an important role in the pathogenesis, having many molecules that participate as antigens that are recognized by immune cells, and also that help the fungus to establish infection. The main molecules reported to trigger an immune response are chitin, glucans, oligosaccharides, proteins, melanin, phospholipids, and others, being present in the principal pathogenic fungi with clinical importance worldwide, such as Histoplasma capsulatum, Paracoccidioides brasiliensis, Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis, and Sporothrix schenckii. Knowledge and understanding of how the immune system recognizes and responds to fungal antigens are relevant for the future research and development of new diagnostic tools and treatments for the control of mycosis caused by these fungi.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389203721666191231105546 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!