AI Article Synopsis
- The study focuses on creating polysaccharide multilayer capsules designed to control the release of Eugenol (Eug) for its use as an antimicrobial agent.
- The capsules are made using a Layer-by-Layer (LbL) technique, incorporating chitosan and carboxymethylcellulose, with sizes ranging from 188 to 1415 nm and achieving a maximum Eugenol incorporation efficiency of about 70.8%.
- The release of Eugenol from these capsules decreases with more layers, showing reduced initial burst releases and enhanced antifungal activity against various pathogens, making them a promising option for antifungal applications.
Article Abstract
This work describes the production of polysaccharide multilayer capsules to control the release of Eugenol (Eug) and enabling its use as an antimicrobial agent. For this propose, oil-in-water nanoemulsions of sodium dodecyl sulfate were coated with alternating depositions of chitosan and carboxymethylcellulose using the Layer-by-Layer (LbL) technique, resulting in capsules containing 1-5 layers. The average size ranged from 188 ± 30 (LbL) to 1415 ± 517 nm (LbL). The maximum incorporation efficiency was 70.8 ± 2.7 % for Eug-SDS-LbL. The initial burst releases decreased in proportion to the increase in the number of polysaccharide layers (22.3 ± 3.1 %-12.8 ± 1.6 %), and are influenced by the pH. These systems exhibited antifungal activity against Aspergillus niger, Trichoderma sp, Gliocladium sp, and Candida albicans, and Eug minimum inhibitory concentrations were lower as compared to those of the free agent. Therefore, these capsules represent promising antifungal materials for application in various fields.
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| http://dx.doi.org/10.1016/j.carbpol.2019.115562 | DOI Listing |
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