Clinical (Chvostek symptom and Trousseau-Bonsdorf test) and electromyographical investigations of the neuromuscular excitability were performed in patients with different forms of epilepsy. Ionized Ca, Na, K, Cl, and total Mg were measured in the cerebrospinal fluid (CSF). Seventy-five percent of the patients showed clinical and electromyographic signs of the tetanic syndrome. In patients with general seizures the CSF ionized Ca content was decreased as related to that of normal subjects. Brain and neuromuscular excitability increase was related with the shifts in Ca metabolism.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Acute hypoalgesic and neurophysiological responses to lower-limb ischaemic preconditioning.
Exp Brain Res
January 2025
Faculty of Sport, Technology and Health Sciences, St. Mary's University, Twickenham, Middlesex, UK.
The aim of this study was to assess if ischaemic preconditioning (IPC) can reduce pain perception and enhance corticospinal excitability during voluntary contractions. In a randomised, within-subject design, healthy participants took part in three experimental visits after a familiarisation session. Measures of pressure pain threshold (PPT), maximum voluntary isometric force, voluntary activation, resting twitch force, corticospinal excitability and corticospinal inhibition were performed before and ≥10 min after either, unilateral IPC on the right leg (3 × 5 min); a sham protocol (3 × 1 min); or a control (no occlusion).
View Article and Find Full Text PDFThe acute effects of dynamic stretching on the neuromuscular system are independent of the velocity.
Exp Physiol
January 2025
Strength and Conditioning Research Laboratory, College of Physical Education, University of Brasília, Brasília, Brazil.
This study examined the acute effects of dynamic stretching at different velocities on the neuromuscular system. Fourteen participants underwent four experimental sessions in random order: (1) control (lying at rest with the ankle in a neutral position); (2) slow velocity dynamic stretching (50 beats/min; SLOW); (3) moderate velocity dynamic stretching (70 beats/min; MOD); and (4) fast velocity dynamic stretching (90 beats/min; FAST). The stretching protocols consisted of four sets of 10 repetitions and targeted the plantar flexor muscles of the right ankle.
View Article and Find Full Text PDFSodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.
Trends Cell Biol
December 2024
Department of Neurology and Center for Neuroscience & Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address:
Voltage-gated sodium channels (VGSCs) are best known for their role in the generation and propagation of action potentials in neurons, muscle cells, and cardiac myocytes, which have traditionally been labeled as 'excitable'. However, emerging evidence challenges this traditional perspective. It is now clear that VGSCs are also expressed in a broad spectrum of cells outside the neuromuscular realm, where they regulate diverse cellular functions.
View Article and Find Full Text PDFFrom Fragmented Facts to Unified Knowledge: Exploring Concept Mapping in Neuromuscular Physiology Among First-Year Medical Students.
Cureus
November 2024
Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, IND.
Background First-year medical students may find it challenging to integrate complex physiological concepts, particularly neuromuscular physiology. While concept mapping has shown promise in medical education, its specific application in teaching intricate physiological mechanisms still needs to be explored. With this background, the objective of the study was to assess the feasibility of using concept mapping among first-year medical students and to explore the perception of students about concept mapping as an educational tool.
View Article and Find Full Text PDFSpinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.
Sci Rep
December 2024
BioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital, University of Helsinki and Aalto University School of Science, Helsinki, Finland.
Article Synopsis
- A new technique called high-PAS combines high-frequency peripheral nerve stimulation (PNS) and high-intensity transcranial magnetic stimulation (TMS) to potentially enhance motor function in patients with incomplete spinal cord injuries.
- The interstimulus interval (ISI) in high-PAS allows for flexibility, making it easier to implement in clinical settings where precise timing is tough, but this also creates challenges for measuring its effectiveness.
- Research with ten healthy participants showed that high-PAS improved motor-evoked potentials (MEPs) and significantly increased spinal excitability (measured by H-reflex amplitudes) during spinal-targeted sessions, but not in cortical-targeted sessions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!