Takii et al (2019) demonstrate in a recent issue of The EMBO Journal that the pericentromeric protein, SGO2, serves as a novel transcriptional coactivator of HSF1, contributing to PIC assembly and expression of Heat Shock Protein (HSP) genes. This finding highlights repurposing of a protein with a nuclear function to drive transcription of proteotoxic stress machinery genes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960451 | PMC |
| http://dx.doi.org/10.15252/embj.2019104077 | DOI Listing |
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