AI Article Synopsis
- An 81-year-old non-smoking man was diagnosed with advanced synchronous multiple primary lung cancers, including squamous cell carcinoma and adenocarcinoma with specific genetic mutations.
- He received PD-1 inhibitors as first-line chemotherapy, but the treatment showed a poor response.
- This case is unique, as there are no similar documented instances of SMPLC, and his non-smoking status along with the EGFR deletion may have contributed to the ineffective treatment.
Article Abstract
We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in the lower lobe. Programmed death-1 (PD-1) inhibitors were administered as first-line chemotherapy; however, treatment response was poor response. There have been no reported SMPLC cases similar to this. During treatment, his non-smoking status and EGFR deletion might have been the cause of the patient's poor response to first-line PD-1 inhibitor treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921201 | PMC |
| http://dx.doi.org/10.1016/j.rmcr.2019.100976 | DOI Listing |
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