AI Article Synopsis
- Diabetic nephropathy (DN) is a common complication in diabetes, leading to kidney problems and severe renal issues like end-stage renal disease.
- Research on DN is evolving, focusing on complex genetic and metabolic factors, particularly the role of microRNAs (miRNAs) as potential diagnostic and therapeutic targets.
- This review highlights recent findings on the clinical significance and molecular functions of miRNAs in DN, aiming to inspire new approaches for diagnosis and treatment.
Article Abstract
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pathogenesis of DN to determine effective treatments of crucial importance is deeply explored. Early DN research focuses on hemodynamic changes and metabolic disorders, and recent studies have shown the regulatory role of microRNAs (miRNAs) in genes, which may be a new diagnostic marker and therapeutic target for diabetic nephropathy. In this review, we summarize the recent advances in the clinical value and molecular mechanisms of miRNAs in DN, providing new ideas for the diagnosis and treatment of DN.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914872 | PMC |
| http://dx.doi.org/10.1155/2019/8719060 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!