AI Article Synopsis
- This study investigated how first-generation (FGA) and second-generation antipsychotics (SGA) affect metabolic syndrome risk factors in mentally ill patients in Qatar, focusing on adherence to prescription guidelines and monitoring.
- Data from 439 patients revealed that those on SGAs displayed higher rates of obesity, elevated blood pressure, and increased triglycerides compared to those on FGAs, indicating worse metabolic health.
- The findings highlighted a high prevalence of metabolic issues, particularly among SGA users, with concerns about polypharmacy and inadequate monitoring of metabolic health, suggesting the need for more prospective studies to improve patient care.
Article Abstract
This study aimed to assess the differential effects of first-generation (FGA) and second-generation antipsychotics (SGA) on the prevalence of risk factors for metabolic syndrome among mentally ill patients in Qatar. We also wanted to check if there is proper adherence with the guidelines for prescribing antipsychotics and the monitoring of metabolic effects in this population. We collected the available retrospective data (socio-demographic, psychiatric, anthropometric, and metabolic measures) from the records of 439 patients maintained on antipsychotics. The majority were males, married, employed, having a psychotic disorder, and receiving SGA. Patients on SGA showed more obesity, higher BP, and more elevated triglycerides compared to those on FGA. The prevalence of the abnormal metabolic measures was high in this sample, but those on SGA showed a significantly higher prevalence of abnormal body mass index and BP. Obesity and hypertension were common in patients maintained on antipsychotics, especially those on SGA. Polypharmacy was common, and many metabolic measures were not monitored properly in those maintained on antipsychotics. More prospective studies with guided monitoring of the patients' clinical status and metabolic changes are needed to serve better this population of patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089884 | PMC |
| http://dx.doi.org/10.1007/s10597-019-00537-y | DOI Listing |
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